When thunderstorm phobia, state anxiety, and/or general anxiety are highly vexing, highly problematic, or particularly severe, a CPT behavior modification program may become further potentiated when implemented in conjunction with appropriately selected psychopharmaceutical medication. Although in less severe cases of canine phobia or anxiety, a properly designed and diligently implemented behavior modification program will result in successful goal outcomes without the inclusion of medication, circumstances occur where behavior modification alone is insufficient and the client pet’s progress plateaus far short of goal. Therefore, without an adjunct to the behavior modification program the phobic or anxious pet may continue destroying property, injure himself/herself, or suffer deleterious acute or chronic physiological effects. Adjuncts to behavior modification may include nutraceuticals, relaxation garments, pheromones, homeopathic remedies, and prescription medication. This article will function on prescription medications that may help to alleviate canine phobias and anxiety when administered in combination with a structured behavior modification program that teaches the dog cognitive coping mechanisms.